Pyridoxal-5-Phosphate Powder

Pyridoxal-5-Phosphate powder(PLP) is the biologically active form of Vitamin B6 that is involved in a variety of metabolic pathways in the human body. It is essential for the production of neurotransmitters, red blood cells, and amino acids.

PLP is derived from pyridoxine, which is found in many foods such as bananas, beans, nuts, and whole grains. However, PLP is not found in significant amounts in natural food sources and must be synthesized in the body.

PLP is a coenzyme that is involved in over 100 enzymatic reactions in the body. It is essential for the metabolism of carbohydrates, fats, and proteins. PLP is also important for the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. Additionally, PLP plays a key role in the production of hemoglobin, the protein in red blood cells that carries oxygen.

PLP is synthesized in the body through a series of reactions that involve several enzymes and cofactors. Pyridoxine is first converted to pyridoxal, which is then phosphorylated to form PLP. The process requires several cofactors including magnesium and zinc.

Certificate of Analysis:

To test the stability of a PLP product, several analytical methods can be used. These methods include:

High-Performance Liquid Chromatography (HPLC): HPLC is a method used to separate, identify, and quantify various components in complex mixtures. To test the stability of PLP, HPLC can be used to measure its purity over time. Purity is an essential aspect of the product as impurities can affect safety, efficacy, and shelf life. The test will determine whether the PLP content remains consistent or if it breaks down into other substances, which may affect its potency or stability.

◆Fourier Transform Infrared (FTIR) Spectroscopy: FTIR is a technique that identifies and determines the chemical and physical properties of a substance by analyzing its absorption spectrum. The analysis can detect changes in the molecular structure of PLP products, such as degradation or contamination, which may occur during manufacturing, storage, or handling.

◆Differential Scanning Calorimetry (DSC): DSC measures the difference in heat flow between a sample and a reference material as a function of temperature or time. It can detect changes in the PLP product's thermal properties, such as melting or boiling points, which may indicate degradation or contamination.

◆Accelerated Stability Testing: Accelerated stability testing is a method used to simulate the effect of temperature and humidity on a product over time. It involves exposing the product to elevated temperatures and humidity levels and monitoring its stability over a specified period. This test can provide valuable information on the shelf life of a PLP product and its storage conditions.

What’s Key Function of Pyridoxal-5-Phosphate Powder?

Pyridoxal-5-Phosphate (PLP) is the active form of Vitamin B6 that plays a critical role in the human body's metabolism. It is involved in various enzymatic reactions that impact the nervous system, cardiovascular health, and immune function. As a dietary supplement, PLP has been studied for its potential therapeutic benefits in a variety of conditions.

1. Nervous System Function

PLP is essential for the production of several key neurotransmitters, including serotonin, dopamine, and norepinephrine. Neurotransmitters are chemical messengers that transmit signals between neurons in the brain. Low levels of PLP have been associated with depression, anxiety, and impaired cognitive function. Supplementation with PLP may help support healthy nervous system function and improve mood and cognitive performance.

2. Cardiovascular Health

PLP can lower levels of homocysteine, an amino acid that is associated with an increased risk of cardiovascular disease. High levels of homocysteine can damage the lining of blood vessels and increase the risk of blood clots. Supplementation with PLP can help reduce homocysteine levels and improve cardiovascular health.

3. Immune Function

PLP is crucial for the production of lymphocytes, a type of white blood cell that helps fight infection. Low levels of PLP have been linked to a weakened immune system and an increased risk of infections. Supplementation with PLP may help support healthy immune function and reduce the risk of infections.

4. Premenstrual Syndrome

PLP may also be used to alleviate symptoms of premenstrual syndrome (PMS). PMS is a common condition that affects many women during their reproductive years. Symptoms can include mood changes, bloating, and cramps. PLP has been shown in some studies to reduce PMS symptoms, particularly when combined with other B vitamins.

5. Carpal Tunnel Syndrome

PLP may also be beneficial for individuals with carpal tunnel syndrome, a condition that causes pain and numbness in the hands and wrists. Some studies have suggested that PLP supplementation can improve symptoms of carpal tunnel syndrome, possibly by reducing inflammation in the affected area.

Cosmetic Functions

Pyridoxal-5-phosphate powder(PLP) is the active form of Vitamin B6 that can also be used in cosmetics. PLP plays a crucial role in maintaining healthy skin by regulating various enzymatic reactions that impact skin health and appearance. As a cosmetic ingredient, PLP has been studied for its potential to improve skin texture, reduce the appearance of fine lines and wrinkles, and enhance overall skin radiance.

1. Skin Health

PLP is involved in many enzymatic reactions that support healthy skin function. For example, it is necessary for the synthesis of ceramides, which are vital components of the skin's barrier function. Ceramides help to lock in moisture and protect the skin from environmental stressors. PLP is also involved in cellular metabolism and collagen synthesis, which contribute to healthy skin texture and elasticity.

2. Anti-Aging Benefits

PLP has been shown to have anti-aging benefits, particularly in reducing the appearance of fine lines and wrinkles. It works by stimulating cellular metabolism and collagen synthesis, which help to improve skin texture and reduce the signs of aging. In one study, participants who used a topical PLP cream for 12 weeks saw significant improvements in skin texture and hydration, as well as a reduction in the appearance of fine lines and wrinkles.

3. Hydration

PLP is a humectant, which means that it helps to attract and retain moisture in the skin. This makes it an ideal ingredient for products designed to hydrate dry or flaky skin. PLP has also been shown to improve skin elasticity and firmness, which can contribute to a more youthful appearance.

4. Brightening

PLP can also help to improve skin tone and enhance overall skin radiance. It works by inhibiting the production of melanin, the pigment responsible for dark spots and uneven skin tone. By reducing melanin production, PLP can help to even out skin tone and reduce the appearance of dark spots.

What is our advantage？

1. Currently we have two factories. A GMP implementation standard factory with a 100,000-level purification workshop, and a fine processing workshop covering an area of 400 square meters.

2.Now we have Halal/kosher/SC/ISO9001/ISO22000 certificate

3. The professional team will provide you with perfect after-sales service.

4. Professional laboratories provide you with various tests.

5. Customize production for customers according to customers' quality and price of products.

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