Vitamin K2 MK-7

Vitamin K2 MK-7 is a form of vitamin K2, chemically known as methylated chain-type vitamin K2-7. It is a fat-soluble vitamin that can be obtained from dietary sources or synthesized by beneficial bacteria in the intestines. The main role of vitamin K2 MK-7 in the body is to regulate bone health and cardiovascular health.

Vitamin K2, also known as menaquinone, is typically represented by MK. It consists of a group of compounds, with a total of 14 different forms, distinguished by the length of their side chains. The representative molecules are MK-4 and MK-7. Among them, MK-7 is characterized by its wide-ranging functionality, potent activity, long half-life, and safety. The Office of Dietary Supplements (ODS) at the National Institutes of Health (NIH) in the United States has evaluated vitamin K2 as a revolutionary and versatile vitamin with broad prospects for health maintenance and promotion.

Specification:

Oil from: 1500ppm-20000ppm

Powder Form:1000ppm-2000ppm

Water Soluble Powder: 1000ppm 2000ppm

Powder suitable for alkaline:2000ppm

Fermentation of Natto Compare with Chemical synthesis Vitamin K2 mk7:

Detection method:

1) Detector requirements: HPLC-UV

2) Mobile phase: water: absolute ethanol: methanol: tetrahydrofuran = 1:15:80:103)Detection wavelength: UV268nm

4)Column: 4.6mm*25cm;5 um; packing L625)Column temperature: 25°℃

6) Flow rate: 0.8ml/min

Note: Method Source: USP39-NF34 (trans and cis retention time ratio is 1.0:1.1)Conclusion: Vitamin K2(MK-7) provided by SungenBio is 100% all-trans.

HIGH-ACTIVITY GREEN PRODUCTION PROCESS:

Good bone health depends on bone formation carried out by osteoblasts and calcium supplements. New research reveals that Vitamin K2(MK-7) moves calcium deposits from blood vessels and correctlydeposited into the bones. it is of great importance to bone and cardiovascular health.

y-glutamyl carboxylase is an enzyme that carboxylates a specific set of proteins and promotes bone deposition. Vitamin K2(MK-7) playsan essential role as cofactor for the enzyme y-glutamyl carboxylase,which is involved in carboxylation and calcium absorption.

Excessive calcium absorption can pose a very serious risk to the bone, cardiovascular, brain, kidney liver and other cel tissues and organs.These imbalances also can cause calcium to deposit in the blood vessels and contribute to vascular calcification or heart disease.

Vitamin K2 MK-7 is essentilal for trapping and binding calclum into bone .it can reduce the risk of cardiovascular and heart disease throughthe carboxylated osteocalcin and bone matrix protein .

The research indicated that vitamin K2 enhances osteocalcin transformationand improves the deposition of calcium into the bones.Vitamin K2 has also been proven effective for the preventionand treatment of osteoporosis.

Astudy "Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausalwomen"in 2013 confirmed that osteocalcin is carboxylated by vitamin K2.Vitamin K2 supplemention reduces serumconcentrations of under--carboxylated osteocalcin and helps decrease bone loss.lt is necessary in the process forabsorption of osteocalcin into the bonel

A study "Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausalwomen"demonstrated that Vitamin K2 is essential for maintaining bone strength in postmenopausal women, andalso improved bone mineral content and femoral neck width

Patients with obsolete thrombosis were treated with 30OFU nattokinase in 48h experiment. The results indicated that the thrombus for over 56 hours had completely Dissolved within 2 hours. Thrombolysis rate of anothers who were treated with 150FU nattokinase is much higher than the same amount of urokinase

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