Paeonia suffruticosa refers to the dry root bark of Paeonia suffruticosa, which is mainly produced in Anhui, Sichuan, Hubei, etc. It is a famous authentic medicinal material in Anhui Province. With the increasing attention of traditional Chinese medicine, the research on tree peony bark extract paeonol, the main component of Cortex Moutan, has gradually deepened.
What is Paeonol?
Paeonol is an active ingredient extracted from the dried rhizomes of the traditional Chinese medicine Cortex Moutan. Ancient Chinese medical books contain various formulas of Cortex Moutan. Studies have shown that it has various pharmacological effects such as antipyretic, anti-inflammatory, antibacterial, analgesic, sedative and hypnotic.
Effects of Paeonol
1. Antibacterial effect
Paeonol has antibacterial, analgesic and anti-inflammatory effects. The in vitro antibacterial experiments used three methods: steel pipe method, filter paper method and digging method. Escherichia coli proliferation has a certain inhibitory effect.
2. Enhance immunity
The rats were inhaled paeonol by atomization. The results showed that the non-specific immune function of the lungs of the rats was greatly enhanced, the spleen, thymus and other immune organ indexes increased significantly, and the lymphocyte transformation rate increased. This shows that Paeonol, the main component of Cortex Moutan, has a great promoting effect on enhancing specific immune function.
3. Protect tissue from ischemia
Paeonol can significantly reduce the ratio of cholesterol and phospholipids on the mitochondrial membrane, and play an important role in reducing the content of free fatty acids in cardiomyocytes. Studies have shown that paeonol can effectively enhance the biological activity of Ca2+-ATPase, and improve and regulate the fluidity and permeability of cell membranes. This indicates that paeonol plays an important role in improving ischemia-reperfusion injury in rats.
4. Antiarrhythmic
Paeonol can enhance the activities of superoxide dismutase and peroxidase in vivo, shorten the duration of ventricular fibrillation and ventricular tachycardia, and reduce the scope of cardiac infarction, which is also one of the antiarrhythmic mechanisms of paeonol.
5. Improve the body's microcirculation
Paeonol can increase the diameter of microcapillaries on the intestinal mucosa of rats, increase the blood flow rate, and effectively promote the local microcirculation of the rat mesentery. It can also improve the body's blood viscosity, inhibit platelet aggregation and adhesion, enhance the deformability of red blood cells, and help promote microcirculation.
Summary
Paeonol, as the main chemical component of Cortex Moutan, has antibacterial, antiarrhythmic, immune-enhancing, and microcirculation-promoting effects.