Azelaic Acid Effects and Usage

Azelaic acid powder( AzA) is a generally used topical medicine in dermatology, which is antibacterial, and anti-inflammatory, regulates follicular keratinisation, inhibits oil painting stashing, reduces saturation, inhibits cell proliferation, and other mechanisms of action. Clinically, it can be used to treat a variety of skin conditions, such as acne, rosacea, chloasma, etc. Because of its wide range of uses and significant remedial goods, it has become a dermatological" star medicine" in recent times.

01. History of azelaic acid

- In 1979, Nazzaro- porro etal. originally applied AzA to the clinical treatment of melasma, acne, and other dermatological conditions, and achieved excellent remedial effect, but due to the limitation of the technology at that time, it was insolvable to gain it with high chastity, so some adverse responses were set up in clinical practice.

- Since the 1980s, a large quantum of literature on remedial goods has appeared in colorful authoritative dermatological and clinical journals.

- Since 1990, its creams have been introduced by Schering( Germany) and Allergan( USA) for use in OTC medicinals and cosmetics. In Taiwan, 20% of azelaic acid cream is vented.

02. Pharmacological effects:

Azelaic acid powder can be used both as an ornamental and medicine, and it has colorful goods similar to acne junking, oil painting control, and whitening.

(1)Antibacterial exertion: inhibit anaerobic bacteria( similar as Propionibacterium acnes), aerobic bacteria protein conflation;

(2)Anti-inflammatory effect: inhibit the product and action of reactive oxygen revolutionaries;

(3)Regulates follicular keratinisation and reduces filamentous keratin conflation;

(4)Inhibit oil painting stashing to reduce dihydrotestosterone- convinced redundant oil painting in the skin;

(5)Reduce hyperpigmentation and inhibit abnormal melanocyte exertion;

03. Clinical operation:

(1)Treatment of Rosacea

The Chinese Rosacea Guidelines( 2021 edition) recommend AzA for the treatment of rosacea. Several clinical studies have demonstrated that topical product is safe, effective, and well-permitted for the treatment of moderate papular-pustular rosacea, and is significantly better than metronidazole in perfecting seditious lesions and erythema.

(2)Acne treatment

The Chinese Acne Treatment Guidelines( 2019 modification) recommend that AzA, which inhibits Propionibacterium acnes and has anti-inflammatory or mildly exfoliating goods, is an alternate-line topical agent for mild to moderate acne, with efficacity seen after about 4 weeks in 2x/ d and a 6- month course of treatment.

In seditious acne control, 15% gel was similar in efficacity to 0.1 adapalene gel. In terms of antibacterial 15% gel was inversely effective as benzoyl peroxide and clindamycin, and AzA gel was better permitted with significantly smaller adverse goods( original burning sensation, vexation) than benzoyl peroxide.

(3)Melasma

The Chinese Expert Consensus on Melasma Treatment( 2021 Edition) recommends 15%- 20% AzA for the topical treatment of melasma, 2 times/ d, the original effect can be seen in 4- 8 weeks, and the course of treatment is about 6 months, and it's substantially used for simple pigmented melasma. it is the most generally used remedial option after hydroquinone in the treatment of mild melasma.

Forpost-inflammatory hyperpigmentation, solar keratosis, hormone-dependent dermatitis, and topical operation have also shown significant clinical goods.

04 . Clinical Benefits of Azelaic Acid

(1)Cases of acne combined with sensitive skin

Due to incorrect skincare and treatment styles during acne treatment, acne cases frequently suffer from concerted skin hedge damage.

For acne cases who can not tolerate retinoids(e.g. retinoic acid cream, adapalene gel), AzA is an excellent choice. Only a small chance of cases witness mild to moderate vexation similar to itching, burning, and chinking sensations at the morning of the drug, but they're generally mild and flash. Azelaic acid is also not photosensitive and can be used anywhere.

(2)Cases of acne combined with hyperpigmentation/ acne marks

In addition to acting on all aspects of acne pathogenesis, it accelerates epidermal development, while competitively inhibiting tyrosinase in melanocytes and reducing color conflation. thus it can also effectively lighten hyperpigmentation/ acne marks. Ideal for cases suffering from acne with further brown/ brown acne marks.

(3)Cases during gestation medication/ gestation

Azelaic acid is gestation medicine class B, which is the loftiest safety position among acne specifics. Topical phrasings are presently considered to be safe, non-toxic,non-teratogenic, and non-mutagenic during gestation and lactation, making it an excellent choice for acne and rosacea cases during these special times.

05. Directions for use

Tablet or spot operation 1- 2 times daily, after sanctification, use moisturizing water and spot apply on acne.

Topical operation 2 times a day

Forbearance needs to be erected when starting to use

1. Spot or topical operation may be applied first to observe skin adaption.

2. Apply in small quantities and gradationally increase retention time from 5 twinkles.

preventives Use moisturising water or cream after sanctification before applying the product.

As one of the most professional azelaic acid powder manufacturers and suppliers in China, Qyherb is featured in good service and competitive prices. If you would like to wholesale, please contact us at info@dnbiology.com.