In recent years, plant polyphenols such as honokiol powder have shown the functions of preventing and inhibiting various malignant tumors in cancer research.
Honokiol is a good medicine for anti-tumor diseases and has good curative effect on various cancers. In vitro studies have shown that honokiol has inhibitory effects on glioblastoma, colon cancer, cervical cancer, gallbladder cancer and other cancer cells.
Honokiol can inhibit the expression of enhancer of zeste homolog 2 (EZH2) at the mRNA and protein levels through transcriptional regulation. This provides a new way to treat bladder tumor diseases. The study found that honokiol can inhibit the invasion, colony formation and other metastatic processes of renal cancer cells (RCC), and the ability to inhibit its metastasis increases with the increase of the dose of honokiol, which provides a possibility for the treatment of renal cell carcinoma. .
Hahm E and other studies found that honokiol can also inhibit the activity of androgen receptors in prostate cancer cells to achieve the purpose of inhibiting cancer cells.
Co-administration of honokiol with existing chemotherapeutic drugs can improve efficacy, reduce toxicity, and help overcome chemoresistance. Honokiol induces apoptosis by regulating Ca2+ channels, upregulates pro-apoptotic proteins, inhibits anti-apoptotic proteins and affects mitochondria-dependent pathways, thereby inhibiting inflammatory responses and inhibiting tumor cell proliferation.
Reference:
1. ZHANG Qing，ZHAO Wei，YE Chang-xiao，et al． Honokiol inhibits bladder tumor growth by suppressing EZH2 /miR-143 axis［J］． Oncotarget，2015，6( 35) : 37335-37348．
2. CHENG S J，CASTILLO V，ELIAZ I，et al． Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1 / KISS1R signaling［J］． International Journal of Oncology，2015，46( 6) : 2293-2298.
3. HAHM E R，KARLSSON A L，BONNER M Y，et al． Honokiol inhibits androgen Receptor Activity in Prostate Cancer Cells ［J］． Prostate，2014，74( 4) : 408-420．