Chichoric acid was first discovered in chicory leaves in 1958. So far, cichoric acid has been reported to be distributed in many plants, and at least 63 genera and species of plants have been found to contain cichoric acid. In recent years, international research on cichoric acid has mainly focused on its biological activity and pharmacological effects.
Chicoric Acid Benefits
1. Antiviral effect
The first reported biological activity of cichoric acid is inhibition of human immunodeficiency virus 1 (HIV-1) infection, which inactivates HIV-1 integrase. Another study found the best antiviral activity monomer cichoric acid, and the inhibitory effect was significantly better than ribavirin.
2. Anti-inflammatory effect
Cichoric acid modulates lipopolysaccharide-induced inflammatory responses in different animal models. Experiments have found that cichoric acid can improve ankle swelling, inflammation and lesions in rats, and is a potential drug against gout.
3. Anti-aging and whitening
Chichoric Acid Ameliorates UV-Induced Skin Fibroblast Aging. Seaweed extract rich in cichoric acid can significantly reduce melanin in melanoma cells.
4. Immunomodulatory effect
In addition to being used as a human immunomodulator, cichoric acid is also widely used in animal husbandry and aquaculture. It is also reported that cichoric acid can inhibit the expression of recombinant human B cell activating factor and has the potential to treat autoimmune diseases.
5. Regulate sugar metabolism
Chichoric acid can increase insulin release and sensitivity, increase glucose uptake, regulate enzyme activity, and improve diabetes and its complications. In addition, it can attenuate impaired insulin sensitivity and protect diabetes-induced endothelial dysfunction by improving mitochondrial function.
6. Other active effects
Chichoric acid can protect organs through anti-inflammation, anti-oxidation, regulation of lipid metabolism, and improvement of mitochondrial function.
anti bacterial infection
Detoxification
Anti-oxidize effect
Summary
New biological activities of cichoric acid have been continuously discovered, but most of the reports are preliminary proofs of effects, and its mechanism of action has not been studied in depth. However, the potential field and development direction of cichoric acid are increasing year by year.