How much sennosides in senna leaf extract?

1. Senna Leaf Extract Sennosides Types:

Senna Leaf Extract Sennosides is a natural phytochemical excerpt attained from the leaves of the Senna factory( Cassia auriculata). The main active factors of Senna Leaf Extract are two composites Sennoside A and Sennoside B. The maturity of the pharmacological exertion of the excerpt is attributed to these two factors.

Sennoside A is an anthraquinone glycoside, which is a type of natural emulsion set up in shops of the rhubarb family. It's made up of an anthraquinone ring structure joined to a sugar patch. Sennoside A is a well-liked natural treatment for constipation and other gastrointestinal problems because of its strong laxative and anti-inflammatory parcels.

Sennoside B, on the other hand, is an anthraquinone glycoside that's structurally analogous to Sennoside A. Its anthraquinone ring is attached to a distinct sugar patch, which modifies its chemical makeup and implicit medical uses. Sennoside B is an important part since it has redundant anti-inflammatory parcels that are known to live.

The difference in chemical structure between Sennoside A and Sennoside B lies in the sugar patch attached to the anthraquinone ring. Sennoside A contains a glucose patch, while Sennoside B contains a rhamnose patch. This difference in sugar half gives Sennoside B slightly different chemical parcels and remedial operations compared to Sennoside A.

2. Amount of sennosides in senna leaf extract

Sennosides in Senna Leaf Extract range from 0.5 to 3 by weight. still, the exact attention of Sennosides in different batches of Extract can vary depending on factors such as the source of the Senna leaves, the birth system used, and the processing conditions.

Studies have shown that the content of Sennosides can range from 0.9 to 2.3 by weight, with an average value of around 1.5. also, its yield can vary depending on the excerpt's quality and the manufacturing process. For illustration, an advanced-quality excerpt may have an advanced yield of Sennosides compared to a lower-quality excerpt.

Its content in different batches of Leaf Extract can also vary depending on the source of the Senna leaves. For case, Senna leaves from different regions or seasons may have different attention of Sennosides. also, the birth system used can affect its content in the final product. For illustration, a detergent with an advanced opposition may give further Sennosides than a detergent with a lower opposition.

The processing conditions, similar to the temperature and pressure used during the birth process, can also impact its content. For this case, high temperatures may lead to a declination of the Sennosides, performing in a lower yield. also, high pressures may cause the Sennosides to be more widely uprooted, performing in an advanced yield.

3. Determination of Sennosides Content

1) HPLC: HPLC is a largely sensitive and specific technology for detecting low situations of Sennosides in Senna Leaf Extract. still, it requires a technical outfit and can be time-consuming, Our company uses this system for testing.

2) Gas Chromatography( GC).

3) Mass Spectrometry( MS).

4) Spectrophotometry.

5) TLC( Thin Subcaste Chromatography).

4. Sennosides standard

Sennosides are the active composites set up in Senna leaves, and their content is frequently used as a measure of the quality and energy of Senna-grounded medications, including Senna splint excerpt. The norms for Sennosides content are generally set by nonsupervisory agencies in different countries and regions, and these norms may vary depending on the intended use of the excerpt.

norms

1) United States Pharmacopeia( USP) The USP sets a standard for Sennosides content of not lower than 0.5 and not further than 3.0 by weight.

2) European Pharmacopoeia( EP) The EP sets a standard for Sennosides content of not lower than 0.5 and not further than 3.0 by weight.

3) Chinese Pharmacopoeia( CN) The CN sets a standard for Sennosides content of not lower than 0.5 and not further than 3.0 by weight.

4) Japanese Pharmacopoeia( JP) The JP sets a standard for Sennosides content in Senna excerpt of not lower than 0.5 and not further than 3.0 by weight.

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