Calcium alpha-ketoglutarate (CaAKG) is a nutritional supplement that has become increasingly popular in recent years. It is a salt of alpha-ketoglutaric acid, an important intermediate molecule in the Krebs cycle that occurs in the mitochondria of cells. In this cycle, alpha-ketoglutaric acid helps to convert food into energy by participating in the breakdown of carbohydrates and fats. By supplementing, individuals may be able to support their body's energy production and overall health.

Chemical Properties

CaAKG is classified as a salt of alpha-ketoglutaric acid, meaning that it contains both a positively charged calcium ion and a negatively charged alpha-ketoglutarate ion. The chemical formula is CaC5H6O5, which indicates that it has one calcium ion, five carbon atoms, six oxygen atoms, and five hydrogen atoms.

It is a white, odorless crystalline powder that is soluble in water and has a slightly acidic taste. It is stable when exposed to air and light and has a melting point of approximately 200 degrees Celsius.

Certificate of Analysis:

Item	Specification	Result	Method
Assay	99.0%	99.07%	Titration
Physical & Chemical Data
Appearance	Off- white to white powder	Conforms	Organoleptic
Odor & Taste	Characteristic	Conforms	Organoleptic
Analytical Quality
Identification		Identical	TLC
Sieve	NLT 90% Through 80 mesh	Conforms	Mesh Screen
Loss on Drying	≤3.0%	2.07%	USP
Residue on ignition	≤0.1%	0.01%	USP
Ca²⁺	21±1%	21.8%	EDTA
Total Heavy Metals	≤10ppm	Conforms	USP
Arsenic(As)	≤0.1ppm	Conforms	USP
Lead(Pb)	≤3.0ppm	Conforms	USP
Mercury(Hg)	≤0.1ppm	Conforms	USP
Cadmium(Cd)	≤0.1ppm	Conforms	USP
Microbiological Tests
Total Plate Count	≤1000cfu/g	Conforms	USP
Yeast & Mold	≤50cfu/g	Conforms	USP
E.Coli	Negative	Negative	USP
Salmonella	Negative	Negative	USP
Staphylococcus	Negative	Negative	USP
Conclusion	Conform with specification

Stability testing of Calcium alpha-ketoglutarate (CaAKG)

Physical stability testing includes conducting tests to evaluate the appearance, color, odor, and particle size of CaAKG. Chemical stability testing involves testing the product for degradation, impurities, and changes in pH, moisture content, and assay. Microbiological stability testing involves assessing the product's ability to resist microbial growth and contamination.

To perform stability testing, samples of CaAKG are stored under controlled conditions of temperature and humidity for a predetermined period of time, which may range from several weeks to several years. The samples are then tested at different time intervals to evaluate changes in their physical, chemical, and microbiological properties.

The conditions under which CaAKG is stored during stability testing should simulate the actual storage conditions that the product may encounter during transportation, distribution, and storage by the end user. These conditions may vary depending on the intended use of the product and the regulatory requirements of the country where it will be sold.

Overall, stability testing is an important part of the quality control process to ensure that they meet the highest standards of safety, efficacy, and quality.

What’s the Key Function of Calcium alpha-ketoglutarate?

1. Enhanced Athletic Performance

Several studies have suggested that CaAKG supplementation may improve athletic performance by increasing muscle mass, decreasing fatigue, and improving aerobic endurance. This is thought to occur because CaAKG may help increase nitric oxide production, which can promote blood flow and oxygen delivery to the muscles.

For example, a study published in the Journal of the International Society of Sports Nutrition found that male athletes who took CaAKG supplements for eight weeks experienced significant increases in strength, power, and muscle mass compared to a placebo group. Another study published in the Journal of the International Society of Sports Nutrition found that CaAKG supplementation improved endurance performance and decreased perceived exertion during exercise.

However, not all studies have shown a clear benefit of CaAKG on athletic performance. A systematic review published in the Journal of the International Society of Sports Nutrition found that while some studies have reported positive effects, others have reported no significant changes in performance.

2. Improved Immune Function

CaAKG supplementation may also help support immune function by promoting the production of glutathione, an important antioxidant that plays a key role in immune system function. Glutathione is produced in the liver and is involved in several important cellular functions, including DNA synthesis and repair, protein synthesis, and metabolic regulation.

Several animal studies have suggested that CaAKG supplementation can increase glutathione levels in the liver, which may help improve immune function. Additionally, a study published in Free Radical Biology & Medicine found that CaAKG supplementation increased lymphocyte proliferation in healthy volunteers, suggesting a potential immune-enhancing effect.

3. Reduced Inflammation

CaAKG may have anti-inflammatory properties due to its ability to scavenge free radicals and inhibit the expression of pro-inflammatory cytokines. For example, a study published in the Journal of Inflammation found that CaAKG supplementation decreased the expression of inflammatory cytokines and markers in rats with pulmonary inflammation.

Other studies have suggested that CaAKG may help reduce oxidative stress, another important contributor to chronic inflammation. A study published in Oxidative Medicine and Cellular Longevity found that CaAKG supplementation reduced oxidative stress and prevented kidney damage in rats with diabetes.

4. Cardiovascular Health

Several studies have suggested that CaAKG may improve cardiovascular health by reducing blood pressure and improving endothelial function. Endothelial cells line blood vessels and play an important role in regulating blood flow and vessel health.

For example, a study published in the Journal of the American College of Nutrition found that CaAKG supplementation in hypertensive rats led to a significant reduction in blood pressure compared to a control group. Another study published in the Journal of Cardiovascular Pharmacology found that CaAKG improved endothelial function in rats with heart disease.

5. Bone Health

Some research suggests that CaAKG supplementation may help support bone health by increasing bone mineral density and reducing the risk of osteoporosis. For example, a study published in Osteoporosis International found that CaAKG supplementation in postmenopausal women led to a significant increase in bone mineral density compared to a placebo group.

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