Magnolol is known to have a wide range of health benefits, including the ability to improve cognitive function, protect the skin and boost the immune system. As a natural antioxidant, it has the characteristics of natural, pollution-free, non-toxic and side effects.
What is Magnolol?
Magnolol is one of the main active components of Magnolia Officinalis extract, which has a wide range of biological activities. Its chemical structure is diallyl-substituted biphenol
Magnolol is a biphenol compound isolated from the stem bark of the traditional Chinese medicine Magnolia Officinalis. It and Honokiol are isomers of each other, and it is the main component of Magnolia Officinalis. The relative molecular mass is 266.32. The molecular formula is C18H18O2.
The monomer of magnolol is colorless needle crystal, which is difficult to dissolve in water, but easily soluble in organic solvents, such as chloroform, ether, and acetone. Phenolic hydroxyl and allyl groups are the main active groups that exert physiological functions. Magnolol is relatively stable and can be stored for 1 125.6 h at 25 °C. It degrades slowly at 80 °C and below, and the half-life at 100 °C is 69. 6 h, with good thermal stability.
Magnolol is a lignan plant polyphenol with anti-inflammatory, antioxidant, anti-splitting and neuroprotective effects.
Magnolol's Antioxidant Properties
Magnolol can prevent oxidative stress by activating the body's antioxidant system to reduce free radical production and scavenge free radicals. It is mainly played by antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). Many studies have found that magnolol has various antioxidant functions such as direct scavenging of free radicals and improving the activity of antioxidant enzymes.
1. Scavenge free radicals
The scavenging of free radicals by honokiol is an important way for it to exert its antioxidant effect. Excessive accumulation of free radicals can lead to lipid peroxidation, which is a chain reaction. The phenolic hydroxyl group of magnolol can provide electron-bonding radicals. It interferes and cuts off its chain reaction chain by directly scavenging free radicals, etc., and relieves lipid peroxidation, thereby exerting an antioxidant effect.
2. Enhance antioxidant enzyme activity
Honokiol can enhance the expression and activity of antioxidant enzyme genes in the body by regulating the activation of various signaling pathways. This relieves the body's oxidative damage.
Conclusion
Oxidative stress is a common pathophysiological process of most diseases, so Magnolol with antioxidant effect can prevent and treat various oxidative stress diseases. Long-term application may have the effect of preventing the occurrence and development of body aging, and has the potential to develop into new drugs.